Risk factors
     Diabetes
          Increased risk with increasing age and duration of diabetes
Tx
     Phosphodiesterase inhibitors (e.g. sildenafil)
          Things to remember when treatment with phosphodiesterase inhibitors is being considered:
               1. Sildenafil is contraindicated in patients being treated with nitrates, and in those who are hypersensitive to sildenafil.
               2. Sildenafil is used with precaution in conditions predisposing to priapism.
               3. Concurrent use of drugs which interfere with the metabolism of sildenafil (e.g. erythromycin, cimetidine) may predispose to adverse reactions by prolonging its plasma half life.
               4. While combining with an alpha-blocker (e.g. doxazosin), it is important to give the drugs with at least a 4-hour interval to reduce the risk of hypotension.

Content on this page has not been checked for accuracy. The author's credentials have not been confirmed. Always use multiple peer-reviewed scholarly sources and good clinical judgement in your decision making.

The Compendium platform was created by David Kwinter, MD, CCFP(EM).

Dr. Kwinter is a Cayman Family Doctor. He runs a Family Medicine Clinic at Cayman Medical in George Town, Grand Cayman, Cayman Islands.