All Approximately Equivalent Doses
Prescribers should strongly consider each drug's time to peak and half-life when contemplating substitution.
| Name (Brand name) | Approximate Equivalent Oral dose (mg) | Time to peak (hours) | Half-life (hours) |
| Alprazolam (Xanax) | 0.5-1 | 1-2 | 12 |
| Bromazepam (Lexotan) | 3-6 | 1-4 | 20 |
| Chlordiazepoxide (Librium) | 10-25 | 1-4 | 100 |
| Clonazepam (Klonopin) | 0.25-0.5 | 1-4 | 34 |
| Clorazepate (Tranxene) | 7.5-15 | 0.5-2 | 100 |
| Diazepam (Valium) | 5-10 | 1-2 | 100 |
| Flurazepam (Dalmane) | 15-30 | 0.5-1 | 100 |
| Lorazepam (Ativan) | 1-2 | 1-4 | 15 |
| Nitrazepam (Mogadon) | 2.5-10 | 0.5-2 | 30 |
| Oxazepam (Serax) | 15-30 | 1-4 | 8 |
| Quazepam (Doral) | 10-20 | 1.5 | 25-41 |
| Temazepam (Restoril) | 10-20 | 2-3 | 11 |
| Triazolam (Halcion) | 0.25-0.5 | 1-2 | 2 |
Content on this page has not been checked for accuracy. The author's credentials have not been confirmed. Always use multiple peer-reviewed scholarly sources and good clinical judgement in your decision making.
The Compendium platform was created by David Kwinter, MD, CCFP(EM).
Dr. Kwinter is a Cayman Family Doctor. He runs a Family Medicine Clinic at Cayman Medical in George Town, Grand Cayman, Cayman Islands.
Dr. Kwinter is a Cayman Family Doctor. He runs a Family Medicine Clinic at Cayman Medical in George Town, Grand Cayman, Cayman Islands.