All Approximately Equivalent Doses

Prescribers should strongly consider each drug's time to peak and half-life when contemplating substitution.

 

Name (Brand name)	Approximate Equivalent Oral dose (mg)	Time to peak (hours)	Half-life (hours)
Alprazolam (Xanax)	0.5-1	1-2	12
Bromazepam (Lexotan)	3-6	1-4	20
Chlordiazepoxide (Librium)	10-25	1-4	100
Clonazepam (Klonopin)	0.25-0.5	1-4	34
Clorazepate (Tranxene)	7.5-15	0.5-2	100
Diazepam (Valium)	5-10	1-2	100
Flurazepam (Dalmane)	15-30	0.5-1	100
Lorazepam (Ativan)	1-2	1-4	15
Nitrazepam (Mogadon)	2.5-10	0.5-2	30
Oxazepam (Serax)	15-30	1-4	8
Quazepam (Doral)	10-20	1.5	25-41
Temazepam (Restoril)	10-20	2-3	11
Triazolam (Halcion)	0.25-0.5	1-2	2

 

Content on this page has not been checked for accuracy. The author's credentials have not been confirmed. Always use multiple peer-reviewed scholarly sources and good clinical judgement in your decision making.

The Compendium platform was created by David Kwinter, MD, CCFP(EM).