Bacteriocidal. Inhibits mycolic acid biosynthesis. Also disrupts DNA, lipid, carbohydrate and NAD synthesis and metabolism.
Respiratory Infection Formulary
Part of DOTS (directly observed therapy)
DOTS has a success rate exceeding 95% and prevents the emergence of further MDR-strains.
Peripheral neuropathy (uncommon), can be minimized by coadministration of Vitamin B6 (pyridoxine)
Available IM or in combination pills
Safe in pregnancy
Caution in liver failure, increased risk for hepatotoxicity