Methylxanthine phosphodiesterase inhibitor; increases cAMP; antagonizes adenosine receptors (methylxanthine)
Treats
Asthma, chronic control
COPD
Acute bronchspasm, adjunct tx only
Toxicity
Mechanism of toxicity unclear, possible etiologies include
Phosphodiesterase inhibition
Adenosine antagonism
Stimulation of epinephrine release
Often results from decreased clearance due to concurrent administration of
Ciprofloxacin
Erythromycin
Sx
CNS stimulation
Headache
Insomnia
GI disturances
Nausea
Vomiting
Cardiac toxicity
Arrhythmia, drug-induced
Labs
Serum level measurable