| Abciximab | Unstable angina undergoing percutaneous coronary intervention ST-elevation myocardial infarction or non-ST elevation myocardial infarction undergoing percutaneous coronary intervention |
| Acamprosate | Alcohol use disorder, moderate to severe |
| Acetaminophen | Pain and/or fever |
| Acetaminophen and codeine | Pain management |
| Acetazolamide | Acute mountain sickness/high-altitude cerebral edema Elevated intraocular pressure associated with acute angle-closure glaucoma Idiopathic intracranial hypertension Metabolic alkalosis |
| Acitretin | Psoriasis Disorders of keratinization |
| Aclidinium | Chronic obstructive pulmonary disease, maintenance |
| Acyclovir | Herpetic keratitis Bell palsy, new onset Cytomegalovirus, prevention in low-risk allogeneic hematopoietic cell transplant recipients Herpes simplex virus, central nervous system infection Herpes simplex virus, mucocutaneous infection Herpes simplex virus, prevention in immunocompromised patients Herpes zoster, treatment Herpes zoster ophthalmicus Varicella, treatment Varicella zoster virus, acute retinal necrosis Varicella zoster virus, encephalitis Varicella zoster virus, prevention in immunocompromised patients Herpes labialis, recurrent HSV, mucocutaneous |
| Adalimumab | Crohn disease, moderate to severe, induction and maintenance of remission Hidradenitis suppurativa, moderate to severe, refractory Plaque psoriasis, moderate to severe Rheumatoid arthritis Spondyloarthritis Ulcerative colitis, moderate to severe, induction and maintenance of remission Uveitis, noninfectious Crohn disease, moderate to severe, induction and maintenance of remission Hidradenitis suppurativa, moderate to severe, refractory Plaque psoriasis, moderate to severe Rheumatoid arthritis Spondyloarthritis Ulcerative colitis, moderate to severe, induction and maintenance of remission Uveitis, noninfectious |
| Adapalene | Acne vulgaris Rosacea |
| Albuterol | Asthma Bronchospasm due to anaphylaxis Chronic obstructive pulmonary disease Hyperkalemia |
| Alendronate | Osteoporosis, fracture risk reduction Paget disease, treatment Prostate cancer, bone loss associated with androgen deprivation therapy |
| Aliskiren | Hypertension |
| Allopurinol | Gout, treatment Nephrolithiasis, prevention of recurrent calcium or uric acid stones Tumor lysis syndrome, prevention |
| Almotriptan | Migraine, moderate to severe, acute treatment |
| Alogliptin | Diabetes mellitus, type 2, treatment |
| Alpelisib | Breast cancer, advanced or metastatic, HR-positive, HER2-negative, PIK3CA-mutated PIK3CA-related overgrowth spectrum |
| Alprazolam | Anxiety Vertigo, acute episodes, treatment |
| Alteplase | Acute ischemic stroke Catheter clearance Frostbite Mechanical prosthetic valve or bioprosthetic valve thrombosis Parapneumonic effusions, complicated and empyema Peripheral arterial occlusion, acute Pulmonary embolism, acute hemodynamically stable Pulmonary embolism, acute hemodynamically unstable Pulmonary embolism, associated with cardiac arrest ST-elevation myocardial infarction |
| Alvimopan | Postoperative ileus |
| Amantadine | Drug-induced parkinsonism Multiple sclerosis-related fatigue Neuroleptic malignant syndrome, moderate to severe Parkinson disease, dyskinesias or mild motor symptoms Tardive dyskinesia |
| Amcinonide | Steroid-responsive dermatoses |
| Amiloride | Ascites Hypertension, chronic Hypokalemia due to chronic stable renal potassium wasting, treatment |
| Amiodarone | Supraventricular arrhythmias Ventricular arrhythmias |
| Amitriptyline | Chronic fatigue syndrome related sleep disorders and pain Fibromyalgia Functional dyspepsia Headache, chronic tension-type Interstitial cystitis Irritable bowel syndrome Major depressive disorder Migraine, prevention Neuropathic pain, chronic Postherpetic neuralgia Sialorrhea |
| Amlodipine | Angina pectoris Hypertension, chronic Raynaud phenomenon |
| Amoxicillin | Actinomycosis Anthrax Asplenia, prophylaxis against bacterial infection in select high-risk patients Bronchiectasis Cervical infection in pregnancy due to Chlamydia trachomatis Endocarditis, prophylaxis Lyme disease Otitis media, acute Periodontitis, severe, plaque-associated Pneumonia, community acquired Prosthetic joint infection, chronic suppression Rhinosinusitis, acute bacterial Skin and soft tissue infection Streptococcal pharyngitis Urinary tract infection Anthrax Catheter, exit-site or tunnel infection Endocarditis, prophylaxis Lyme disease Otitis media, acute Peritonitis, prophylaxis for patients requiring invasive dental procedures Pneumonia, community-acquired Pneumococcal infection prophylaxis for anatomic or functional asplenia Rhinosinusitis, acute bacterial; uncomplicated Streptococcus, group A; pharyngitis/tonsillitis Urinary tract infection, prophylaxis |
| Amoxicillin and clavulanate | Bite wound infection, prophylaxis or treatment Chronic obstructive pulmonary disease, acute exacerbation Diabetic foot infection Intra-abdominal infection, mild to moderate, community-acquired in patients without risk factors for resistance or treatment failure Neutropenic fever, low-risk cancer patients Odontogenic infection Otitis media, acute Peritonsillar cellulitis or abscess Pneumonia Rhinosinusitis, acute bacterial Urinary tract infection |
| Anti-D immune globulin | Immune thrombocytopenia RhD suppression Transfusion |
| Apalutamide | Prostate cancer, metastatic, castration sensitive Prostate cancer, nonmetastatic, castration resistant |
| Apixaban | Heparin-induced thrombocytopenia Nonvalvular atrial fibrillation Venous thromboembolism |
| Aripiprazole | Agitation/aggression associated with psychiatric disorders, substance intoxication, or other organic causes Agitation/aggression and psychosis associated with dementia, severe or refractory Bipolar disorder Delusional disorder Delusional infestation Huntington disease-associated chorea Major depressive disorder, treatment resistant Obsessive-compulsive disorder, treatment resistant Schizophrenia |
| Aspirin | Analgesic and antipyretic Anti-inflammatory for arthritis associated with rheumatic disease Atherosclerotic cardiovascular disease Carotid artery stenting Carotid endarterectomy Colorectal cancer risk reduction, primary prevention Migraine, acute treatment Pericarditis, acute or recurrent Polycythemia vera, prevention of thrombosis Preeclampsia prevention Valvular heart disease Venous thromboembolism prevention, indefinite therapy Venous thromboembolism prophylaxis for total hip or total knee arthroplasty Venous thromboembolism prophylaxis in lower-risk patients with multiple myeloma receiving immunomodulatory therapy |
| Atenolol | Angina Atrial fibrillation/flutter, maintenance of ventricular rate control Hypertension Marfan syndrome with aortic aneurysm Migraine, prevention Myocardial infarction, early treatment and secondary prevention Supraventricular tachycardia, maintenance of ventricular rate control Thyrotoxicosis Ventricular arrhythmia or ventricular premature beats, prevention |
| Atorvastatin | Heterozygous familial hypercholesterolemia Homozygous familial hypercholesterolemia Prevention of atherosclerotic cardiovascular disease Transplantation |
| Azathioprine | Behcet syndrome Bullous pemphigoid Crohn disease Dermatomyositis/polymyositis Eosinophilic granulomatosis with polyangiitis Granulomatosis with polyangiitis and microscopic polyangiitis, maintenance therapy Hepatitis, autoimmune Immune thrombocytopenia, chronic Interstitial pneumonia/interstitial lung disease Lupus nephritis Myasthenia gravis, chronic immunosuppressive therapy Pemphigus vulgaris and pemphigus foliaceus Polyarteritis nodosa Rheumatoid arthritis Sarcoidosis, pulmonary, steroid-refractory disease Solid organ transplantation Takayasu arteritis Ulcerative colitis Uveitis, noninfectious |
| Azithromycin | Acne vulgaris, inflammatory, moderate to severe Babesiosis Bronchiectasis, prevention of pulmonary exacerbations Bronchiolitis obliterans Cesarean delivery, preoperative prophylaxis Chronic obstructive pulmonary disease, acute exacerbation Cystic fibrosis, anti-inflammatory Diarrhea, infectious Endocarditis prophylaxis, dental or invasive respiratory tract procedure Lyme disease, erythema migrans Mycobacterial infection Pertussis Pneumonia, community acquired Sexually transmitted infections Surgical prophylaxis, uterine evacuation Typhoid and paratyphoid fever |
| Bacitracin and polymyxin B | Superficial ocular infections |
| Baclofen | Hiccups Muscle spasm and/or musculoskeletal pain Spasticity |
| Bendamustine | Chronic lymphocytic leukemia Non-Hodgkin lymphomas Hodgkin lymphoma, relapsed or refractory Multiple myeloma, salvage therapy Waldenstrom macroglobulinemia, refractory |
| Benralizumab | Asthma, severe eosinophilic |
| Benztropine | Drug-induced extrapyramidal symptoms Parkinsonism |
| Benzydamine | Mucositis, due to radiation therapy Pharyngitis |
| Betahistine | Meniere disease |
| Betamethasone | Antenatal fetal maturation Bursitis Dermatologic conditions Foot disorders Multiple sclerosis Rheumatoid and osteoarthritis Tenosynovitis, peritendinitis |
| Bicalutamide | Prostate cancer, metastatic Prostate cancer, locally advanced, high recurrence risk |
| Bilastine | Allergic rhinitis Chronic spontaneous urticaria |
| Bisacodyl | Bowel cleansing Constipation |
| Bisoprolol | Angina Atrial fibrillation/flutter, maintenance of ventricular rate control Heart failure with reduced ejection fraction Hypertension Ventricular arrhythmias |
| Bromazepam | Anxiety, monotherapy or adjunctive therapy |
| Bromocriptine | Diabetes mellitus, type 2, treatment Hyperprolactinemic disorders Neuroleptic malignant syndrome, moderate to severe Parkinson disease |
| Budesonide | Crohn disease, mild to moderate Eosinophilic esophagitis Hepatitis, autoimmune Microscopic colitis Primary immunoglobulin A nephropathy Ulcerative colitis |
| Budesonide and formoterol | Asthma Chronic obstructive pulmonary disease, maintenance |
| Bupivacaine | Analgesia/Anesthesia |
| Bupropion | Attention-deficit/hyperactivity disorder Bipolar depression Major depressive disorder Seasonal affective disorder Selective serotonin reuptake inhibitor-induced sexual dysfunction, augmentation Smoking cessation |
| Bupropion and naltrexone | Weight management, chronic |
| Buspirone | Generalized anxiety disorder Unipolar depression, augmentation |
| Caffeine | Augmentation of seizure induction during electroconvulsive therapy Postdural puncture headache Reversal of dipyridamole- or regadenoson-induced adverse reactions during nuclear cardiac stress testing Stimulant |
| Calcipotriol | Plaque psoriasis |
| Calcium carbonate | Antacid Calcium supplementation Hyperphosphatemia in chronic kidney disease Hypoparathyroidism |
| Calcium gluconate | Beta-blocker overdose Calcium channel blocker overdose Calcium replacement, during CRRT with citrate-based regional anticoagulation Cardiac arrest or cardiotoxicity in the presence of hypocalcemia or hypermagnesemia Hydrofluoric acid exposure Hyperkalemia, severe/emergent Hypocalcemia Parenteral nutrition, maintenance requirement Radium-226 or strontium-90 internal contamination |
| Canagliflozin | Diabetes mellitus, type 2, treatment |
| Candesartan | Acute coronary syndromes Heart failure with reduced ejection fraction Hypertension, chronic Migraine, prevention Proteinuric chronic kidney disease |
| Candesartan and hydrochlorothiazide | Hypertension, replacement therapy |
| Cannabidiol | Seizure associated with Lennox-Gastaut syndrome or Dravet syndrome Seizure associated with tuberous sclerosis complex |
| Cantharidin | Common or periungual warts Molluscum contagiosum Plantar warts |
| Capecitabine | Anal carcinoma Biliary tract cancer, adjuvant therapy Biliary tract cancers, advanced Breast cancer, adjuvant therapy, HER2-negative, with residual disease after neoadjuvant therapy and surgery Breast cancer, advanced or metastatic Colorectal cancer Esophageal, gastric, and gastroesophageal cancers Head and neck cancer, squamous cell, recurrent or metastatic; palliative treatment Neuroendocrine pancreatic/islet cell tumors, metastatic or unresectable Ovarian, fallopian tube, or peritoneal cancer, platinum-refractory Pancreatic cancer, locally advanced or metastatic Pancreatic cancer, potentially curable, adjuvant therapy Unknown primary cancer |
| Carbamazepine | Bipolar disorder, hypomania and mild to moderate mania or episodes with mixed features and bipolar major depression Focal onset seizures and generalized onset seizures Neuropathic pain |
| Carbidopa and levodopa | Parkinson disease Restless legs syndrome, intermittent |
| Carvedilol | Angina, chronic stable Atrial fibrillation/flutter, maintenance of ventricular rate control Heart failure with reduced ejection fraction Hypertension Myocardial infarction, early treatment and secondary prevention Nonsustained ventricular tachycardia or ventricular premature beats, symptomatic Variceal hemorrhage prophylaxis, primary |
| Cefazolin | Bloodstream infection Endocarditis, prophylaxis Endocarditis, treatment Intra-abdominal infection, mild to moderate, community-acquired in patients without risk factors for resistance or treatment failure Osteomyelitis and/or discitis Peritonitis, treatment Pneumonia Prostatitis, acute bacterial Prosthetic joint infection Septic arthritis, without prosthetic material Skin and soft tissue infection Surgical prophylaxis Toxic shock syndrome Urinary tract infection, complicated |
| Cefixime | Gonococcal infection, uncomplicated Gonococcal infection, expedited partner therapy Rhinosinusitis, acute bacterial Streptococcal pharyngitis, group A Typhoid fever Urinary tract infection |
| Ceftazidime | Bloodstream infection Cystic fibrosis, acute pulmonary exacerbation Diabetic foot infection, moderate to severe Endophthalmitis, bacterial Intra-abdominal infection, health care-associated or high-risk community-acquired infection Intracranial abscess and spinal epidural abscess Melioidosis Meningitis, bacterial Neutropenic fever, high-risk cancer patients Osteomyelitis and/or discitis Peritonitis, treatment Pneumonia Prosthetic joint infection Septic arthritis Skin and soft tissue infection, moderate to severe Urinary tract infection, complicated |
| Ceftriaxone | Actinomycosis, severe or extensive Bite wound infection, treatment Bloodstream infection Chronic obstructive pulmonary disease, acute exacerbation Diabetic foot infection, moderate to severe Endocarditis, prophylaxis Endocarditis, treatment Intra-abdominal infection, mild to moderate, community acquired in patients without risk factors for resistance or treatment failure Intracranial abscess or spinal epidural abscess Lyme disease Meningitis, bacterial Meningococcal disease, chemoprophylaxis after close contact with high-risk patient Neurobrucellosis Odontogenic soft tissue infection, pyogenic Osteomyelitis and/or discitis Otitis media, acute Pneumonia, community-acquired Prosthetic joint infection Rat bite fever Septic arthritis Sexually transmitted infections Skin and soft tissue infection Spontaneous bacterial peritonitis Surgical prophylaxis, colorectal Toxic shock syndrome, streptococcal Urinary tract infection, complicated |
| Cefuroxime | Bite wound infection, prophylaxis or treatment Chronic obstructive pulmonary disease, acute exacerbation Intra-abdominal infection, mild to moderate, community acquired in patients without risk factors for resistance or treatment failure Lyme disease Odontogenic soft tissue infection, pyogenic Otitis media, acute Pneumonia, community-acquired, outpatient empiric therapy Streptococcal pharyngitis, group A Surgical prophylaxis Urinary tract infection, cystitis, acute uncomplicated or acute simple cystitis |
| Celecoxib | Anti-inflammatory Dysmenorrhea Gout, treatment Migraine, acute treatment Osteoarthritis Pain, acute |
| Cephalexin | Endocarditis, prophylaxis Mastitis, lactational Prosthetic joint infection Skin and soft tissue infection Streptococcal pharyngitis, group A Urinary tract infection |
| Cetirizine | Allergic rhinitis or conjunctivitis Anaphylaxis Angioedema, acute allergic or recurrent idiopathic Infusion reaction, premedication Urticaria, new onset and chronic spontaneous |
| Chlordiazepoxide | Alcohol withdrawal syndrome, treatment Alcohol withdrawal syndrome, prophylaxis Anxiety disorders |
| Chlorpromazine | Agitation/aggression associated with psychiatric disorders Bipolar disorder Hiccups, prolonged or intractable Migraine, severe, acute treatment Nausea and vomiting, acute self-limiting Nausea and vomiting of pregnancy, refractory Schizophrenia |
| Chlorthalidone | Calcium nephrolithiasis, prevention Edema, refractory Hypertension, chronic |
| Chlorzoxazone | Musculoskeletal conditions |
| Cholestyramine | Chronic diarrhea due to bile acid malabsorption Dyslipidemia Enhanced elimination of leflunomide Hyperthyroidism associated with Graves disease Pruritus associated with cholestasis Thyroid storm |
| Ciclesonide | Asthma |
| Ciclopirox | Cutaneous candidiasis Onychomycosis, mild to moderate Seborrheic dermatitis, scalp Tinea infections |
| Cilazapril and hydrochlorothiazide | Hypertension |
| Cimetidine | Heartburn Interstitial cystitis Stress ulcer prophylaxis in critically ill patients |
| Ciprofloxacin | Anthrax Bite wound infection, prophylaxis or treatment Cat scratch disease, lymphadenitis Chancroid Cholera Chronic obstructive pulmonary disease, acute exacerbation Crohn disease, treatment of simple perianal fistulas, adjunctive agent Diabetic foot infection Endocarditis due to HACEK organisms Intra-abdominal infection, mild to moderate, community-acquired in patients without risk factors for resistance or treatment failure Meningitis, bacterial Meningococcal meningitis prophylaxis Neutropenia, antibacterial prophylaxis in high-risk patients anticipated to have an ANC =100 cells/mm3 for >7 days Neutropenic fever, low-risk cancer patients Osteomyelitis Peritoneal dialysis catheter, exit-site or tunnel infection Plague Pneumonia, as a component of empiric therapy or pathogen-specific therapy for P. aeruginosa in hospitalized patients Pouchitis, acute Prostatitis Prosthetic joint infection Septic arthritis Spontaneous bacterial peritonitis, prophylaxis Surgical prophylaxis Surgical site infection Tularemia Urinary tract infection |
| Citalopram | Aggressive or agitated behavior associated with dementia Binge eating disorder Generalized anxiety disorder Major depressive disorder Obsessive-compulsive disorder Panic disorder Posttraumatic stress disorder Premature ejaculation Premenstrual dysphoric disorder Social anxiety disorder Vasomotor symptoms associated with menopause |
| Clarithromycin | Bronchiolitis obliterans, including diffuse panbronchiolitis and symptomatic cryptogenic bronchiolitis obliterans Chronic obstructive pulmonary disease, acute exacerbation Endocarditis prophylaxis, dental or invasive respiratory tract procedure Mycobacterial infection Pertussis Pneumonia, community-acquired Q fever, acute symptomatic Streptococcal pharyngitis, group A |
| Clindamycin | Anthrax Babesiosis Bacterial vaginosis Bite wound infection, prophylaxis of high-risk bite or treatment Diabetic foot infection, mild to moderate Gingivitis, acute simple, plaque-associated Hidradenitis suppurativa Malaria, treatment Mastitis, lactational Neutropenic fever, empiric therapy for low-risk cancer patients Osteomyelitis Pelvic inflammatory disease, severe Pneumonia Postpartum endometritis Prosthetic joint infection Rhinosinusitis, acute bacterial Septic arthritis due to S. aureus Skin and soft tissue infection Surgical prophylaxis Toxic shock syndrome, toxin production suppression |
| Clindamycin and benzoyl peroxide | Acne vulgaris Rosacea |
| Clindamycin and tretinoin | Acne vulgaris |
| Clioquinol and flumethasone | Steroid-responsive otic infection Steroid-responsive dermatoses/infection |
| Clobazam | Catamenial epilepsy Lennox-Gastaut Seizures, treatment refractory |
| Clobetasol | Mild to moderate plaque-type psoriasis of nonscalp areas Moderate to severe plaque-type psoriasis Oral mucosal inflammation Scalp psoriasis, moderate to severe Steroid-responsive dermatoses |
| Clobetasone | Dermatitis |
| Clomiphene | Ovulation induction |
| Clonazepam | Anxiety Myoclonus Rapid eye movement sleep behavior disorder Seizure disorders, refractory Tardive dyskinesia Vertigo, acute episodes |
| Clonidine | Hypertension ICU sedation, transition from dexmedetomidine to clonidine Opioid withdrawal, medically supervised Vasomotor symptoms associated with menopause |
| Clopidogrel | Acute coronary syndrome Percutaneous coronary intervention for stable ischemic heart disease Carotid artery atherosclerosis, symptomatic Carotid artery stenting Coronary artery bypass graft surgery Ischemic stroke/transient ischemic attack Peripheral atherosclerotic disease Stable ischemic heart disease Transcatheter aortic valve replacement, thromboprophylaxis Transcatheter mitral valve repair with MitraClip device, thromboprophylaxis |
| Clorazepate | Anxiety disorders Focal onset seizures |
| Clotrimazole | Candidiasis Candidiasis, vulvovaginal Cutaneous candidiasis Otomycosis Tinea infections |
| Cloxacillin | Bloodstream infection due to methicillin-susceptible S. aureus Endocarditis due to methicillin-susceptible staphylococci Osteomyelitis due to methicillin-susceptible S. aureus Skin and soft tissue infections |
| Codeine | Pain management Cough in select patients Diarrhea |
| Copper intrauterine device | Contraception Emergency contraception |
| Crisaborole | Atopic dermatitis |
| Cyanocobalamin | Aphthous stomatitis, simple, recurrent Drug toxicity reduction Vitamin B12 deficiency, treatment Vitamin B12 deficiency, prevention |
| Cyclobenzaprine | Fibromyalgia Muscle spasm and/or musculoskeletal pain Temporomandibular disorder, acute |
| Cyclosporine | Aplastic anemia Focal segmental glomerulosclerosis Graft-versus-host disease, acute, prevention Graft-versus-host disease, chronic, treatment Immune thrombocytopenia, refractory Lung transplant, prevention of acute rejection Myasthenia gravis, chronic immunosuppressive therapy Nephrotic syndrome Psoriasis Solid organ transplant T-cell large granular lymphocytic leukemia, symptomatic Ulcerative colitis, severe, steroid-refractory Uveitis |
| Dapagliflozin | Chronic kidney disease Diabetes mellitus, type 2, treatment Heart failure with reduced ejection fraction Heart failure with preserved ejection fraction |
| Dapagliflozin and metformin | Diabetes mellitus, type 2, treatment |
| Darbepoetin alfa | Anemia due to chemotherapy in cancer patients Anemia due to chronic kidney disease Myelodysplastic syndromes, lower-risk, symptomatic anemia management |
| Degarelix | Prostate cancer, advanced |
| Desipramine | Bulimia nervosa Diabetic neuropathy Irritable bowel syndrome-associated pain and global symptoms Major depressive disorder Postherpetic neuralgia |
| Desloratadine | Allergic rhinitis, seasonal or perennial Angioedema, acute allergic or recurrent idiopathic Urticaria, new onset and chronic spontaneous Urticaria, nonsteroidal anti-inflammatory drug associated, prophylaxis |
| Desmopressin | Deceased organ donor management Diabetes insipidus, central Hemophilia A, mild Intracranial hemorrhage associated with antiplatelet agents Nocturia, refractory Prevention of overly rapid sodium correction in patients with chronic severe hyponatremia Uremic bleeding von Willebrand disease, mild to moderate |
| Desvenlafaxine | Major depressive disorder Vasomotor symptoms associated with menopause |
| Dexamethasone | Acute mountain sickness/high-altitude cerebral edema Acute respiratory distress syndrome, moderate to severe Adrenal insufficiency, adrenal crisis Adrenal insufficiency, primary chronic Antiemetic regimens Chemotherapy-associated nausea and vomiting, prevention Antiemetic regimens Postoperative nausea and vomiting, prevention Antiemetic regimens Radiation therapy-associated nausea and vomiting, prevention Asthma, acute exacerbation Cancer-related cachexia Cancer-related pain, advanced cancer, adjuvant therapy Cerebral edema associated with brain tumor COVID-19 Cushing syndrome, diagnosis Fetal lung maturation, acceleration of Immune thrombocytopenia Iodinated contrast media allergic-like reaction, prevention Meningitis, prevention of neurologic complications Migraine, recurrence prevention Multiple myeloma Neoplastic epidural spinal cord compression, symptomatic Tuberculosis, central nervous system Acute mountain sickness/high-altitude cerebral edema Acute respiratory distress syndrome, moderate to severe Adrenal insufficiency, adrenal crisis Adrenal insufficiency, primary chronic Antiemetic regimens Chemotherapy-associated nausea and vomiting, prevention Antiemetic regimens Postoperative nausea and vomiting, prevention Antiemetic regimens Radiation therapy-associated nausea and vomiting, prevention Asthma, acute exacerbation Cancer-related cachexia Cancer-related pain, advanced cancer, adjuvant therapy Cerebral edema associated with brain tumor COVID-19, hospitalized patients Cushing syndrome, diagnosis Fetal lung maturation, acceleration of Immune thrombocytopenia Iodinated contrast media allergic-like reaction, prevention Meningitis, prevention of neurologic complications Migraine, recurrence prevention Multiple myeloma Neoplastic epidural spinal cord compression, symptomatic Tuberculosis, central nervous system |
| Dextromethorphan | Cough suppressant |
| Diazepam | Anxiety Hydroxychloroquine/chloroquine toxicity Intoxication Muscle spasm, spasticity, and/or rigidity Neuroleptic malignant syndrome Seizures Serotonin syndrome Substance withdrawal Vertigo, acute episodes, treatment |
| Diclofenac | Ankylosing spondylitis Dysmenorrhea Gout, treatment Migraine, acute treatment Osteoarthritis Pain, acute Rheumatoid arthritis Actinic keratosis Osteoarthritis Pain, acute |
| Diclofenac and misoprostol | Osteoarthritis Rheumatoid arthritis |
| Dienogest | Endometriosis |
| Digoxin | Atrial fibrillation or atrial flutter, rate control Fetal supraventricular tachyarrhythmia, sustained Heart failure with reduced ejection fraction Supraventricular tachycardia, rate control |
| Dihydroergotamine | Cluster headache Medication-overuse headache or intractable migraine/status migrainosus Migraine, moderate to severe, acute treatment |
| Diltiazem | Angina pectoris Atrial fibrillation or atrial flutter, rate control Hypertension Nonsustained ventricular tachycardia or ventricular premature beats, symptomatic Pulmonary arterial hypertension Supraventricular tachycardia |
| Dimenhydrinate | Motion sickness; motion sickness-associated nausea/vomiting Nausea and vomiting, pregnancy associated, severe or refractory Postoperative nausea/vomiting Radiation sickness Vertigo, acute episodes |
| Dimethyl fumarate | Multiple sclerosis, relapsing |
| Diphenhydramine | Allergic reactions Angioedema, allergic Common cold symptoms or upper airway cough syndrome Extrapyramidal symptoms, medication-induced Infusion- or transfusion-related reactions Insomnia, occasional Iodinated contrast media allergic-like reaction, prevention Motion sickness Nausea and vomiting, pregnancy associated, severe or refractory Scombroid poisoning Urticaria, new onset and chronic spontaneous Vertigo, acute treatment |
| Docusate | Stool softener Ceruminolytic |
| Domperidone | GI motility disorders Nausea/vomiting associated with dopamine-agonist anti-Parkinson agents |
| Donepezil | Alzheimer disease Dementia |
| Dopamine | Bradycardia or atrioventricular block, symptomatic Hypotension or shock Inotropic support Hemodynamic support |
| Doxazosin | Benign prostatic hyperplasia Hypertension Ureteral stone(s) expulsion |
| Doxepin | Insomnia, sleep maintenance Major depressive disorder, treatment resistant |
| Doxycycline | Acne vulgaris, inflammatory, moderate to severe Actinomycosis Anaplasmosis and ehrlichiosis Anthrax Bite wound infection, prophylaxis or treatment Brucellosis Cholera, treatment Chronic obstructive pulmonary disease, acute exacerbation Endocarditis prophylaxis, dental or invasive respiratory tract procedure Hidradenitis suppurativa Lyme disease Malaria Otitis media, acute Periodontitis, severe, plaque-associated Plague Pleurodesis, chemical Pneumonia, community-acquired, empiric therapy Prosthetic joint infection Q fever Rhinosinusitis, acute bacterial Rocky Mountain spotted fever Rosacea, moderate to severe or unresponsive to topical therapy Sexually transmitted infections Skin and soft tissue infection Surgical prophylaxis, uterine evacuation Tularemia |
| Doxylamine | Insomnia, sleep onset or sleep maintenance Nausea and vomiting, pregnancy associated |
| Doxylamine and pyridoxine | Nausea and vomiting, pregnancy associated |
| Drospirenone | Contraception |
| Duloxetine | Chemotherapy-induced peripheral neuropathy Fibromyalgia Generalized anxiety disorder Major depressive disorder Musculoskeletal pain, chronic Neuropathic pain associated with diabetes mellitus Stress urinary incontinence |
| Dutasteride | Benign prostatic hyperplasia |
| Edoxaban | Nonvalvular atrial fibrillation Venous thromboembolism |
| Efinaconazole | Onychomycosis, mild to moderate |
| Eletriptan | Migraine, moderate to severe, acute treatment |
| Eltrombopag | Chronic hepatitis C-associated thrombocytopenia Immune thrombocytopenia Severe aplastic anemia, first-line treatment Severe aplastic anemia, refractory |
| Empagliflozin | Chronic kidney disease Diabetes mellitus, type 2, treatment Heart failure |
| Empagliflozin and metformin | Diabetes mellitus, type 2, treatment |
| Enalapril | Acute coronary syndrome Heart failure with reduced ejection fraction Hypertension, chronic Posttransplant erythrocytosis Proteinuric chronic kidney disease |
| Enoxaparin | Frostbite Hemodialysis, intermittent, anticoagulation of circuit Ischemic heart disease Mechanical heart valve Superficial vein thrombosis, acute symptomatic Venous thromboembolism prophylaxis Venous thromboembolism treatment |
| Entacapone | Parkinson disease |
| Ephedrine | Asthma, mild intermittent symptoms Hypotension, anesthesia-induced Postoperative nausea and vomiting |
| Epinephrine | Asthma, mild intermittent symptoms |
| Eplerenone | Heart failure Hypertension, chronic Primary aldosteronism |
| Equine conjugated estrogens and medroxyprogesterone acetate | Osteoporosis prevention or vulvar and vaginal atrophy associated with menopause Vasomotor symptoms associated with menopause |
| Erenumab | Migraine, prevention |
| Erythromycin | Ocular infections, superficial |
| Escitalopram | Binge eating disorder Body dysmorphic disorder Bulimia nervosa Generalized anxiety disorder Major depressive disorder Obsessive-compulsive disorder Panic disorder Posttraumatic stress disorder Premature ejaculation Premenstrual dysphoric disorder Vasomotor symptoms associated with menopause Binge eating disorder Body dysmorphic disorder Bulimia nervosa Generalized anxiety disorder Major depressive disorder Obsessive-compulsive disorder Panic disorder Posttraumatic stress disorder Premature ejaculation Premenstrual dysphoric disorder Vasomotor symptoms associated with menopause |
| Esomeprazole | Eosinophilic esophagitis Gastroesophageal reflux disease, erosive or nonerosive Pathological hypersecretory conditions Peptic ulcer disease, treatment of complicated ulcers Prevention of NSAID-induced gastric ulcers Upper GI bleed, acute |
| Esomeprazole and naproxen | Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis |
| Esterified estrogens | Prostate cancer, advanced Secondary amenorrhea, hypoestrogenism Vasomotor symptoms associated with menopause Vulvar and vaginal atrophy associated with menopause Breast cancer, metastatic |
| Eszopiclone | Insomnia, sleep onset or sleep maintenance |
| Ethinyl estradiol and levonorgestrel | Abnormal uterine bleeding, acute Contraception Contraception in patients with BMI <30 kg/m2 Emergency contraception |
| Ezetimibe | Homozygous familial hypercholesterolemia Homozygous sitosterolemia Primary hyperlipidemia, including heterozygous familial and nonfamilial hyperlipidemia or mixed hyperlipidemia Secondary prevention of atherosclerotic cardiovascular events after acute coronary syndrome |
| Famciclovir | Herpes simplex virus, mucocutaneous infection Herpes simplex virus, prevention in solid organ transplant recipients Herpes zoster, treatment Varicella infection in patients with HIV |
| Famotidine | Aspiration prophylaxis in patients undergoing anesthesia Chronic spontaneous urticaria Gastroesophageal reflux disease, treatment Infusion reaction, premedication Mastocytosis Stress ulcer prophylaxis in select critically ill patients |
| Febuxostat | Hyperuricemia Tumor lysis syndrome, prevention |
| Felodipine | Chronic stable angina Hypertension |
| Fenofibrate | Hypertriglyceridemia |
| Fentanyl | Acute pain, patient-controlled analgesia Acute postoperative pain Acute nonoperative severe pain Chronic pain, including chronic cancer pain Chronic cancer pain, management of breakthrough pain episodes Critically ill patients in the ICU, pain and sedation Procedural sedation and analgesia Rapid sequence intubation, pretreatment General anesthesia Neuraxial analgesia |
| Ferric derisomaltose | Iron-deficiency anemia, treatment |
| Fesoterodine | Overactive bladder |
| Fexofenadine | Upper respiratory allergies Urticaria, new onset and chronic spontaneous |
| Finasteride | Androgenetic alopecia Benign prostatic hyperplasia Hirsutism |
| Fluconazole | Blastomycosis Candidiasis, treatment Candidiasis, prophylaxis Coccidioidomycosis, treatment Coccidioidomycosis, prophylaxis Cryptococcal meningitis Cryptococcosis, pulmonary infection Onychomycosis Tinea infections |
| Fluocinonide | Atopic dermatitis Psoriasis Other inflammatory and pruritic dermatologic conditions besides atopic dermatitis or psoriasis |
| Fluoxetine | Binge eating disorder Bipolar major depression Body dysmorphic disorder Bulimia nervosa Fibromyalgia, refractory Generalized anxiety disorder Major depressive disorder Obsessive-compulsive disorder Panic disorder Posttraumatic stress disorder Premature ejaculation Premenstrual dysphoric disorder Social anxiety disorder |
| Fluticasone | Allergic rhinitis Chronic rhinosinusitis, with or without nasal polyps Nonallergic rhinitis Asthma, maintenance/controller Bronchiolitis obliterans, post-hematopoietic cell transplantation Chronic obstructive pulmonary disease, maintenance Eosinophilic esophagitis |
| Fluticasone furoate and vilanterol | Asthma Chronic obstructive pulmonary disease, maintenance |
| Fluticasone propionate and salmeterol | Asthma, maintenance/controller Chronic obstructive pulmonary disease, maintenance |
| Fluvastatin | Heterozygous familial hypercholesterolemia Homozygous familial hypercholesterolemia Prevention of atherosclerotic cardiovascular disease |
| Folic acid | Alcohol withdrawal syndrome Megaloblastic and macrocytic anemias due to folate deficiency Methanol toxicity Prevention of neural tube defects Supplementation to reduce toxicity associated with antifolate chemotherapy Supplementation to reduce toxicity associated with chronic methotrexate therapy for nononcology uses |
| Formoterol | Asthma, maintenance/controller Chronic obstructive pulmonary disease, maintenance Exercise-induced bronchospasm |
| Furosemide | Ascites due to cirrhosis Edema or volume overload |
| Gabapentin | Alcohol use disorder, moderate to severe Alcohol withdrawal Cough, chronic refractory Fibromyalgia Generalized anxiety disorder Hiccups Neuropathic pain Postherpetic neuralgia Pruritus, chronic Restless legs syndrome Seizures, focal onset Social anxiety disorder Vasomotor symptoms associated with menopause |
| Galcanezumab | Cluster headache Migraine, prevention |
| Gentamicin | Bloodstream infection Brucellosis CNS infection, health care-associated Endocarditis, treatment Meningitis, bacterial Osteomyelitis, prevention, following open fractures Pelvic infections Peritonitis, treatment Plague Sepsis or septic shock, adjunctive empiric gram-negative coverage Sexually transmitted infections Surgical prophylaxis Tularemia Urinary tract infection, complicated |
| Gliclazide | Diabetes mellitus, type 2, treatment |
| Glucagon | Anaphylaxis in patients on beta-blocker therapy Beta-blocker overdose Calcium channel blocker overdose Diagnostic aid, radiologic examinations Growth hormone deficiency, alternative diagnostic test Hypoglycemia |
| Glyburide | Diabetes mellitus, type 2, treatment |
| Glycopyrrolate | Chronic obstructive pulmonary disease, maintenance Primary focal hyperhidrosis Reduction of secretions Reduction of secretions at end of life Reversal of bradycardia, vagal reflexes Reversal of muscarinic effects of cholinergic agents |
| Goserelin | Breast cancer, advanced Breast cancer, advanced, with endocrine-based combination therapy Breast cancer, early stage, premenopausal ovarian preservation during chemotherapy Breast cancer, premenopausal ovarian suppression during adjuvant endocrine therapy Endometrial thinning Endometriosis Hormone therapy for transgender females, adjunct Prostate cancer, advanced Prostate cancer, stage B2 to C, in combination with an antiandrogen and radiotherapy |
| Guaifenesin | Expectorant |
| Halobetasol and tazarotene | Plaque psoriasis |
| Haloperidol | Agitation/Aggression associated with psychiatric disorders, substance intoxication, or other organic causes Bipolar disorder Chemotherapy-induced breakthrough nausea and vomiting Delirium, hyperactive Nausea and vomiting in advanced or terminal illness Postoperative nausea and vomiting, prevention, moderate- to high-risk patients Schizophrenia Tourette syndrome, management of tics |
| Hepatitis A vaccine | Primary immunization Postexposure prophylaxis Outbreak control |
| Hepatitis A virus and recombinant hepatitis B virus vaccine | Primary immunization |
| Hydralazine | Heart failure with reduced ejection fraction Hypertension, chronic Hypertensive emergency Hypertensive emergency in pregnancy or postpartum Perioperative hypertension |
| Hydrochlorothiazide | Calcium nephrolithiasis, prevention Diabetes insipidus, nephrogenic Edema, refractory Hypertension, chronic |
| Hydrochlorothiazide and triamterene | Hypertension, edema Meniere disease, chronic management |
| Hydrocortisone | Adrenal insufficiency, adrenal crisis, treatment and prevention Adrenal insufficiency, chronic Adrenal insufficiency, physiologic replacement following resection of an ACTH-producing tumor or unilateral adrenalectomy Anti-inflammatory or immunosuppressive Asthma, acute exacerbation COVID-19, hospitalized patients Iodinated contrast media allergic-like reaction, prevention Septic shock Thyroid storm Ulcerative colitis, acute, remission induction Anal pruritus, external Atopic dermatitis Contact dermatitis Genital pruritus, external Hemorrhoids Psoriasis, plaque Seborrheic dermatitis Stasis dermatitis Ulcerative colitis, distal, mild to moderately active Vaginitis, desquamative inflammatory |
| Hydromorphone | Acute pain in opioid-naive patients Acute pain, opioid-tolerant patients Critically ill patients in the ICU, pain and sedation Acute postoperative pain, postoperative recovery/postanesthesia care unit Acute vaso-occlusive pain in sickle cell disease Neuraxial analgesia Chronic pain, noncancer and cancer pain |
| Hydroxychloroquine | Dermatomyositis, cutaneous Lupus erythematosus Malaria Porphyria cutanea tarda Primary Sjogren syndrome Q fever Rheumatoid arthritis Sarcoidosis |
| Hydroxyzine | Anxiety, monotherapy or adjunctive therapy Peripartum management, adjunct to opioids Pruritus Urticaria, new onset and chronic spontaneous |
| Ibuprofen | Abnormal uterine bleeding, nonacute Anti-inflammatory Dysmenorrhea Fever Gout, treatment Migraine, acute treatment Pain Pericarditis, acute or recurrent |
| Icosapent ethyl | Cardiovascular risk reduction with hypertriglyceridemia Hypertriglyceridemia |
| Imipramine | Major depressive disorder Bulimia nervosa Irritable bowel syndrome-associated pain and global symptoms Neuropathic pain Panic disorder |
| Imiquimod | Actinic keratosis Basal cell carcinoma, superficial Cutaneous flat warts Genital and perianal warts Herpes simplex virus infection, genital, acyclovir resistant |
| Indapamide | Calcium nephrolithiasis Edema or general volume overload Hypertension, chronic |
| Indomethacin | Acute pain Ankylosing spondylosis, osteoarthritis, or rheumatoid arthritis Bursitis/tendinopathy of the shoulder Gout, treatment Pericarditis, acute or recurrent Prevention of pancreatitis post-endoscopic retrograde cholangiopancreatography Tocolysis |
| Insulin aspart | Diabetes mellitus, type 1, treatment Diabetes mellitus, type 2, treatment Patients with diabetes receiving enteral feedings Patients with diabetes undergoing surgery and using an insulin pump Diabetic ketoacidosis, mild to moderate, uncomplicated Hyperglycemia, hospitalized patients |
| Insulin degludec | Diabetes mellitus, type 1, treatment Diabetes mellitus, type 2, treatment |
| Insulin detemir | Diabetes mellitus, type 1, treatment Diabetes mellitus, type 2, treatment Hyperglycemia in hospitalized patients |
| Insulin glargine | Diabetes mellitus, type 1, treatment Diabetes mellitus, type 2, treatment Hyperglycemia in hospitalized patients |
| Insulin NPH | Diabetes mellitus, type 1, treatment Diabetes mellitus, type 2, treatment Patients with diabetes receiving enteral feedings Patients with diabetes undergoing surgery |
| Insulin regular | Calcium channel blocker or beta-blocker overdose/toxicity Diabetes mellitus, type 1, treatment Diabetes mellitus, type 2, treatment Patients with diabetes receiving enteral feedings Patients with diabetes receiving parenteral feedings Patients with diabetes undergoing surgery and using an insulin pump Cadaveric organ recovery Diabetic ketoacidosis or hyperosmolar hyperglycemic state Hyperglycemia, hospitalized patients Hyperkalemia, severe/emergent |
| Ipratropium | Allergic/nonallergic perennial rhinitis Colds Seasonal allergic rhinitis Asthma, acute exacerbation, moderate to severe Chronic obstructive pulmonary disease |
| Irbesartan and hydrochlorothiazide | Hypertension |
| Iron sucrose | Chemotherapy-associated anemia Iron-deficiency anemia in chronic kidney disease Iron-deficiency anemia, treatment, patients without chronic kidney disease |
| Isoniazid | Tuberculosis, active Tuberculosis, latent infection |
| Isosorbide mononitrate | Angina pectoris, prevention |
| Isotretinoin | Acne vulgaris, moderate to severe Cutaneous T-cell lymphomas Squamous cell skin cancer, prevention in high-risk patients |
| Itraconazole | Aspergillosis Blastomycosis Candidiasis Coccidioidomycosis Histoplasmosis Onychomycosis Paracoccidioidomycosis Prophylaxis against invasive fungal infections Sporotrichosis Talaromycosis Tinea infections |
| Ketamine | Agitation, acute/severe or refractory Analgesia, subanesthetic dosing Depressive episode associated with major depressive disorder General anesthesia Mechanically ventilated patients in the ICU, analgesia/sedation/agitation Procedural sedation Rapid sequence intubation outside the operating room Status epilepticus, refractory |
| Ketoconazole | Cushing syndrome Fungal infections Prostate cancer, advanced Cutaneous candidiasis Dandruff Seborrheic dermatitis Tinea infections |
| Ketoprofen | Ankylosing spondylitis Rheumatoid arthritis or osteoarthritis Dysmenorrhea, pain |
| Ketorolac | Migraine, severe, acute treatment Pain management |
| Labetalol | Acute aortic syndromes/acute aortic dissection Acute ischemic stroke, BP management with reperfusion therapy Hypertension, acute/severe inpatient Hypertension, chronic/resistant Hypertensive emergency Hypertensive emergency in pregnancy or postpartum Intracerebral hemorrhage, acute, blood pressure management Subarachnoid hemorrhage, blood pressure management |
| Lactulose | Constipation Hepatic encephalopathy, treatment or prevention |
| Lamotrigine | Bipolar disorder, maintenance treatment and acute bipolar major depression Focal onset seizures and generalized onset seizures Short-lasting unilateral neuralgiform headache attacks, prophylaxis Trigeminal neuralgia |
| Lanreotide | Acromegaly Carcinoid syndrome Gastroenteropancreatic neuroendocrine tumors |
| Lansoprazole | Eosinophilic esophagitis Gastroesophageal reflux disease, erosive or nonerosive Hypersecretory conditions Peptic ulcer disease NSAID-associated gastric ulcer Stress ulcer prophylaxis in critically-ill patients |
| Latanoprost | Elevated intraocular pressure |
| Leflunomide | BK virus, in kidney transplant recipients Cytomegalovirus disease, in transplant recipients resistant to standard antivirals, adjunctive therapy Rheumatoid arthritis |
| Lemborexant | Insomnia, sleep onset or sleep maintenance |
| Letrozole | Breast cancer, adjuvant therapy Breast cancer, advanced, first- or second-line treatment Breast cancer off-label combinations Infertility/Ovulation stimulation in anovulatory patients with polycystic ovary syndrome Ovarian cancer, epithelial, recurrent |
| Leuprolide | Breast cancer, premenopausal ovarian suppression Endometriosis Hormone therapy for transgender females, assigned male at birth Paraphilia, males Prostate cancer, advanced Uterine leiomyomata |
| Levetiracetam | Craniotomy, seizure prophylaxis Focal onset seizures and generalized onset seizures Status epilepticus Subarachnoid hemorrhage Traumatic brain injury |
| Levothyroxine | Deceased organ donor management Hypothyroidism Myxedema coma TSH suppression |
| Lidocaine | Anesthesia, topical |
| Lidocaine and | Anesthesia, local injectable Interstitial cystitis Ventricular arrhythmias |
| Linagliptin | Diabetes mellitus, type 2, treatment |
| Liothyronine | Antidepressant augmentation Deceased organ donor management Diagnostic aid, T3 suppression test Hypothyroidism, primary Myxedema coma |
| Liraglutide | Diabetes mellitus, type 2, treatment Weight management, chronic |
| Lisinopril | Acute coronary syndrome Heart failure with reduced ejection fraction Hypertension, chronic Migraine, prevention Posttransplant erythrocytosis, kidney transplant recipients Proteinuric chronic kidney disease, diabetic or nondiabetic Hypertension Proteinuria |
| Lisinopril and hydrochlorothiazide | Hypertension |
| Lithium | Bipolar disorder Major depressive disorder, unipolar |
| Loperamide | Diarrhea, acute Diarrhea, cancer treatment-induced Diarrhea, chronic Enterocutaneous fistula or ileostomy, high-output |
| Loratadine | Allergic rhinitis or conjunctivitis Urticaria, new onset and chronic spontaneous Allergic rhinitis or conjunctivitis Urticaria, new onset and chronic spontaneous |
| Lorazepam | Akathisia, antipsychotic-induced Anxiety Catatonia Chemotherapy-induced nausea and vomiting, prevention and treatment Intoxication Neuroleptic malignant syndrome Sedation/agitation, critical illness Seizures Serotonin syndrome Substance withdrawal Vertigo, acute episodes, treatment |
| Lovastatin | Heterozygous familial hyperlipidemia Prevention of atherosclerotic cardiovascular disease |
| Magnesium carbonate | Dietary supplement |
| Magnesium hydroxide | Antacid, various GI symptoms, including gastroesophageal reflux disease, intermittent symptom relief Laxative |
| Magnesium sulfate | Asthma, severe acute exacerbations Chronic obstructive pulmonary disease, severe acute exacerbation Constipation Eclampsia/preeclampsia with severe features, seizure prophylaxis and treatment Fetal neuroprotection for imminent preterm birth Hypomagnesemia, treatment Parenteral nutrition Torsades de pointes |
| Mebendazole | Ascariasis Capillariasis Echinococcus, cystic Enterobiasis Toxocariasis Trichinellosis Trichostrongyliasis Trichuriasis |
| Mefenamic acid | Abnormal uterine bleeding, nonacute Dysmenorrhea, primary Pain, mild to moderate |
| Meloxicam | Gout, treatment Osteoarthritis Pain, acute Rheumatoid arthritis |
| Memantine | Alzheimer disease, moderate to severe Dementia Neurocognitive toxicity of whole brain irradiation, prevention |
| Meningococcal group B vaccine | Meningococcal group B disease prevention |
| Mesalamine | Crohn disease, mild to moderate Ulcerative colitis, mild to moderate |
| Metformin | Antipsychotic-induced weight gain, treatment Diabetes mellitus, type 2, prevention Diabetes mellitus, type 2, treatment Gestational diabetes mellitus, treatment Polycystic ovary syndrome |
| Methenamine | Urinary tract infection, prophylaxis/suppression |
| Methimazole | Hyperthyroidism associated with Graves disease, toxic multinodular goiter, toxic adenoma, or iodine-induced thyrotoxicosis Thyroid storm Thyrotoxicosis, type I amiodarone-induced |
| Methocarbamol | Muscle spasm |
| Methotrexate | Acute lymphoblastic leukemia Acute promyelocytic leukemia maintenance phase Bladder cancer Breast cancer Gestational trophoblastic neoplasia Graft-vs-host disease, acute, prophylaxis Head and neck cancer Large granular lymphocyte leukemia, symptomatic Mycosis fungoides Non-Hodgkin lymphoma Nonleukemic meningeal cancer Osteosarcoma Primary CNS lymphoma, newly diagnosed Primary cutaneous anaplastic large cell lymphoma Soft tissue sarcoma Atopic dermatitis or eczema, moderate to severe Bullous pemphigoid Crohn disease, moderate to severe Dermatomyositis, cutaneous Dermatomyositis/polymyositis Discoid lupus erythematosus and subacute cutaneous lupus erythematosus, refractory Eosinophilic granulomatosis with polyangiitis Giant cell arteritis Granulomatosis with polyangiitis and microscopic polyangiitis Morphea or localized scleroderma Psoriasis, moderate to severe Rheumatoid arthritis Sarcoidosis, pulmonary Scleritis, idiopathic, noninfectious Still disease, adult-onset, moderate to severe Systemic lupus erythematosus Systemic sclerosis or scleroderma Takayasu arteritis Termination of intrauterine pregnancy, first trimester Tubal ectopic pregnancy |
| Methyldopa | Hypertension |
| Methylnaltrexone | Opioid-induced constipation with advanced illness Opioid-induced constipation with chronic non-cancer pain |
| Methylphenidate | Attention-deficit/hyperactivity disorder Fatigue, severe, cancer related or in palliative care setting Major depressive disorder in medically ill, palliative care, terminal illness, or elderly patients Narcolepsy |
| Methylprednisolone | Acute respiratory distress syndrome, moderate to severe Asthma, acute exacerbation Chronic obstructive pulmonary disease, acute exacerbation COVID-19, hospitalized patients Deceased organ donor management Giant cell arteritis, treatment Gout, treatment Graft-versus-host disease, acute, treatment Immune-mediated adverse reactions associated with checkpoint inhibitor therapy Immune thrombocytopenia Inflammatory bowel disease Iodinated contrast media allergic-like reaction, prevention Multiple sclerosis, acute exacerbation Myopathies, treatment Nausea and vomiting of pregnancy, severe/refractory Prostate cancer, metastatic, castration resistant Sarcoidosis, severe, acute Systemic rheumatic disorders, organ-threatening or life-threatening Warm autoimmune hemolytic anemia |
| Metoclopramide | Aspiration prophylaxis in patients undergoing anesthesia Bowel obstruction, malignant inoperable Chemotherapy-induced acute and delayed nausea or vomiting, prevention Dyspepsia, functional Gastroparesis, diabetic and nondiabetic Hiccups Medication-overuse headache or intractable migraine headache Migraine, severe, acute treatment Nausea and/or vomiting Radiation therapy-induced nausea and vomiting Tension-type headache, acute |
| Metoprolol | Angina pectoris Atrial fibrillation/flutter Heart failure with reduced ejection fraction Hypertension, chronic Migraine, prevention Myocardial infarction, early treatment and secondary prevention Supraventricular tachycardia Thyrotoxicosis Ventricular arrhythmias |
| Metronidazole | Amebiasis, intestinal or extraintestinal Bacterial vaginosis Balantidiasis Bite wound infection, prophylaxis or treatment Crohn disease Giardiasis Intra-abdominal infection Intracranial abscess Odontogenic infection Pneumonia, aspiration Pouchitis, acute Sexually transmitted infections Skin and soft tissue infection Surgical prophylaxis Tetanus Bacterial vaginosis Rosacea Trichomoniasis |
| Miconazole | Candidiasis Candidiasis, vulvovaginal Tinea infections |
| Midazolam | Agitation, acute/severe General anesthesia or monitored anesthesia care Intoxication Mechanically ventilated patients in the ICU, sedation Palliative and end-of-life sedation Procedural sedation, outside the operating room Rapid sequence intubation, outside the operating room Seizures |
| Midodrine | Ascites, cirrhotic, diuretic resistant or with hypotension Hemodialysis-induced hypotension, prevention Hepatorenal syndrome Hypotension in the ICU, vasopressor sparing Hypotension, symptomatic orthostatic Postural orthostatic tachycardia syndrome Syncope, vasovagal |
| Mifepristone | Hyperglycemia in patients with Cushing syndrome Termination of intrauterine pregnancy Early pregnancy loss |
| Minocycline | Acne vulgaris, inflammatory, moderate to severe Leprosy Meningococcal disease, chemoprophylaxis after close contact with a patient with invasive disease Nocardiosis Plague Prosthetic joint infection Rheumatoid arthritis Sexually transmitted infections Skin and soft tissue infection |
| Mirabegron | Overactive bladder |
| Mirtazapine | Headache, chronic tension-type, prophylaxis Major depressive disorder Panic disorder |
| Misoprostol | Early pregnancy loss Incomplete abortion Labor induction or cervical ripening Missed abortion Nonsteroidal anti-inflammatory drug-induced gastric ulcers, prevention Postpartum hemorrhage Termination of intrauterine pregnancy, combination therapy Termination of intrauterine pregnancy, monotherapy |
| Mometasone | Allergic rhinitis Chronic rhinosinusitis Nasal congestion associated with seasonal rhinitis Nasal polyps Nonallergic rhinitis Seasonal allergic rhinitis Rhinosinusitis, adjunctive treatment Rhinosinusitis, treatment Asthma Corticosteroid-responsive dermatoses |
| Mometasone and formoterol | Asthma Chronic obstructive pulmonary disease, maintenance |
| Montelukast | Allergic rhinitis, perennial or seasonal Aspirin-exacerbated respiratory disease, including aspirin challenge/desensitization Asthma, persistent, maintenance therapy Bronchoconstriction, exercise-induced Hypersensitivity reactions, rapid chemotherapy/biologics desensitization Infusion-related reactions, daratumumab-based regimens Urticaria, chronic and delayed pressure |
| Morphine | Acute coronary syndrome, refractory ischemic chest pain Acute pain in opioid-naive patients Acute pain in patients on chronic opioid therapy for pain Acute postoperative pain Acute vaso-occlusive pain in sickle cell disease Chronic pain, including chronic cancer pain Critically ill patients in the ICU, pain and sedation Dyspnea in palliative care patients Neuraxial analgesia |
| Moxifloxacin | Bacterial conjunctivitis Surgical prophylaxis Anthrax Bite wound infection, prophylaxis of high-risk bite or treatment Chronic obstructive pulmonary disease, acute exacerbation Diabetic foot infection Endophthalmitis, severe, acute bacterial postcataract Intra-abdominal infection, mild to moderate, community-acquired in patients without risk factors for resistance or treatment failure Meningitis, bacterial Neutropenic fever, empiric therapy for low-risk patients with cancer Plague Pneumonia, community-acquired, outpatients with comorbidities and inpatients Rhinosinusitis, acute bacterial Sexually transmitted infections Skin and soft tissue infections Surgical prophylaxis Tuberculosis |
| Nabilone | Nausea and vomiting associated with cancer chemotherapy |
| Naloxegol | Opioid-induced constipation Opioid-induced constipation; cancer pain related |
| Naltrexone | Alcohol use disorder, moderate to severe Opioid use disorder, mild to severe Pruritus |
| Naproxen | Anti-inflammatory Dysmenorrhea Fever Gout, prophylaxis during initiation of urate-lowering therapy Gout, treatment Migraine, acute treatment Pain |
| Naratriptan | Menstrual migraine prevention Migraine, moderate to severe, acute treatment |
| Nifedipine | Anal fissure Angina pectoris High-altitude pulmonary edema Hypertension, chronic Hypertensive emergency in pregnancy or postpartum Pulmonary arterial hypertension Raynaud phenomenon Tocolysis |
| Nirmatrelvir and ritonavir | COVID-19, treatment, mild to moderate |
| Nitrofurantoin | Asymptomatic bacteriuria in pregnancy Cystitis, acute uncomplicated or acute simple cystitis, treatment Cystitis, prophylaxis for recurrent infection |
| Nitroprusside | Acute aortic syndromes/acute aortic dissection Acute decompensated heart failure Acute ischemic stroke, BP management with reperfusion therapy Hypertensive emergency |
| Norethindrone | Abnormal uterine bleeding, nonacute Contraception Endometriosis Estrogen therapy-associated endometrial hyperplasia, prevention Secondary amenorrhea, diagnostic aid |
| Nortriptyline | Cyclic vomiting syndrome, moderate to severe, prevention Functional dyspepsia Headache, chronic tension-type, prevention Irritable bowel syndrome-associated pain and global symptoms Major depressive disorder Migraine, prevention Myofascial pain syndrome and related causes of chronic pain including myofascial pelvic pain, nonradicular neck pain, temporomandibular disorders, and vulvodynia Neuropathic pain, chronic, including diabetic neuropathy Postherpetic neuralgia Smoking cessation |
| Nystatin | Candidiasis, oropharyngeal, mild disease Peritoneal dialysis-associated infection, prevention of secondary fungal infection |
| Olanzapine | Agitation/Aggression associated with psychiatric disorders, substance intoxication, or other organic causes Agitation/Aggression and psychosis associated with dementia, severe or refractory Anorexia nervosa Bipolar disorder Chemotherapy-induced acute and delayed nausea or vomiting, prevention Chemotherapy-induced breakthrough nausea or vomiting, treatment Delirium, hyperactive Delusional infestation Huntington disease-associated chorea, moderate to severe Major depressive disorder Nausea and vomiting associated with advanced cancer Schizophrenia |
| Olmesartan | Acute coronary syndromes Hypertension, chronic Proteinuric chronic kidney disease |
| Olopatadine | Allergic conjunctivitis |
| Omalizumab | Asthma, moderate to severe allergic Chronic spontaneous urticaria Nasal polyps |
| Omeprazole | Aspiration prophylaxis in patients undergoing anesthesia Barrett esophagus Dyspepsia, functional Eosinophilic esophagitis Gastroesophageal reflux disease, erosive or nonerosive Nonsteroidal anti-inflammatory drug-induced ulcers, primary prevention Peptic ulcer disease, treatment and secondary prevention Stress ulcer prophylaxis in select critically ill patients Zollinger-Ellison syndrome |
| Ondansetron | Carcinoid syndrome-associated diarrhea, severe, refractory Chemotherapy-induced nausea and vomiting, prevention Gastroparesis, symptomatic treatment of nausea and vomiting Nausea and/or vomiting, acute, severe Postoperative nausea and vomiting, prevention Postoperative nausea and vomiting, treatment or rescue therapy Pregnancy-associated nausea and vomiting, severe or refractory Radiation therapy-associated nausea and vomiting, prevention Vertigo-associated nausea and vomiting |
| Orlistat | Weight management, chronic |
| Orphenadrine | Pain, musculoskeletal, acute |
| Oseltamivir | Influenza, seasonal, prophylaxis Influenza, seasonal, treatment Influenza A, avian, prophylaxis Influenza A, avian, treatment |
| Oxazepam | Alcohol withdrawal syndrome, mild to moderate Anxiety disorders |
| Oxcarbazepine | Focal onset seizures Trigeminal neuralgia |
| Oxybutynin | Overactive bladder Primary focal hyperhidrosis |
| Oxycodone | Acute pain in opioid-naive patients Acute pain in patients on chronic opioid therapy Acute postoperative pain, postoperative recovery/postanesthesia care unit Chronic pain, including chronic cancer pain |
| Pantoprazole | Aspiration prophylaxis in patients undergoing anesthesia Barrett esophagus Dyspepsia, functional Eosinophilic esophagitis Gastroesophageal reflux disease, erosive or nonerosive Nonsteroidal anti-inflammatory drugs-induced ulcers, primary prevention Peptic ulcer disease, treatment and secondary prevention Stress ulcer prophylaxis in select critically ill patients Upper GI bleed, acute Zollinger-Ellison syndrome |
| Paroxetine | Body dysmorphic disorder Generalized anxiety disorder Major depressive disorder Obsessive-compulsive disorder Panic disorder Posttraumatic stress disorder Premature ejaculation Premenstrual dysphoric disorder Social anxiety disorder Vasomotor symptoms of menopause |
| Perindopril | Heart failure with reduced ejection fraction Hypertension, chronic Stable coronary artery disease |
| Perindopril and amlodipine | Hypertension |
| Perindopril and indapamide | Hypertension |
| Phenobarbital | Alcohol withdrawal syndrome Sedation Status epilepticus Seizures Sedative/hypnotic withdrawal Alcohol withdrawal syndrome Sedation Status epilepticus Seizures Sedative/hypnotic withdrawal |
| Phenol | Antiseptic Mouth/throat pain |
| Phenylephrine | Hypotension or shock Hypotension during anesthesia Nasal congestion Priapism, acute ischemic |
| Phenytoin | Seizures Status epilepticus Trigeminal neuralgia, rescue therapy |
| Pinaverium | Biliary disorders, irritable bowel syndrome |
| Piperacillin and tazobactam | Bite wound infection, treatment Bloodstream infection Cystic fibrosis, severe acute pulmonary exacerbation or failure of oral therapy, for coverage of P. aeruginosa Diabetic foot infection, moderate to severe Intra-abdominal infection Malignant external otitis, hospitalized patients Neutropenic fever, high-risk cancer patients Pneumonia Sepsis and septic shock Skin and soft tissue infection, moderate to severe Urinary tract infection, complicated |
| Pizotifen | Migraine, prevention |
| Potassium chloride | Diabetic ketoacidosis or hyperosmolar hyperglycemic state, potassium management Hypokalemia, treatment Parenteral nutrition |
| Pramipexole | Parkinson disease Restless legs syndrome |
| Pravastatin | Heterozygous familial hypercholesterolemia Homozygous familial hypercholesterolemia Prevention of atherosclerotic cardiovascular disease Transplantation |
| Prazosin | Hypertension, chronic PTSD-related nightmares and sleep disruption Raynaud phenomenon |
| Prednisone | Adrenal insufficiency, primary chronic Angioedema (acute allergic) and/or new-onset urticaria Asthma, acute exacerbation Bell palsy, new onset Chronic obstructive pulmonary disease, acute exacerbation COVID-19, hospitalized patients Duchenne muscular dystrophy Focal segmental glomerulosclerosis, primary Giant cell arteritis, treatment Gout, treatment Graft-versus-host disease, acute, treatment Hepatitis, autoimmune Immune thrombocytopenia Inflammatory bowel disease Iodinated contrast media allergic-like reaction, prevention Minimal change disease, treatment Multiple myeloma Multiple sclerosis, acute exacerbation Myasthenia gravis, crisis Myopathies, treatment Pericarditis, acute or recurrent Poison ivy dermatitis, severe Polymyalgia rheumatica Prostate cancer, metastatic, castration resistant Systemic rheumatic disorders Takayasu arteritis Thyroiditis, subacute Tuberculosis, pulmonary Urticaria, chronic spontaneous, acute exacerbation Warm autoimmune hemolytic anemia Adrenal insufficiency, primary chronic Alcoholic hepatitis, severe Angioedema (acute allergic) and/or new-onset urticaria Asthma, acute exacerbation Bell palsy, new onset Chronic obstructive pulmonary disease, acute exacerbation COVID-19, hospitalized patients Duchenne muscular dystrophy Focal segmental glomerulosclerosis, primary Giant cell arteritis, treatment Gout, treatment Graft-versus-host disease, acute, treatment Hepatitis, autoimmune Immune thrombocytopenia Immune-mediated adverse reactions associated with checkpoint inhibitor therapy Inflammatory bowel disease Iodinated contrast media allergic-like reaction, prevention Minimal change disease, treatment Multiple myeloma, previously untreated, transplant ineligible Multiple sclerosis, acute exacerbation Myasthenia gravis Myopathies, treatment Pericarditis, acute or recurrent Poison ivy dermatitis, severe Polymyalgia rheumatica Prostate cancer, metastatic, castration resistant Systemic rheumatic disorders Takayasu arteritis Thyroiditis, subacute Tuberculosis, pulmonary Urticaria, chronic spontaneous, acute exacerbation Warm autoimmune hemolytic anemia |
| Pregabalin | Cough, chronic refractory Fibromyalgia Generalized anxiety disorder Neuropathic pain Pruritus, chronic Restless legs syndrome Seizures, focal onset Social anxiety disorder Vasomotor symptoms associated with menopause |
| Prochlorperazine | Chemotherapy-induced nausea and vomiting Migraine, moderate to severe, acute treatment Nausea and/or vomiting, acute Postoperative nausea and/or vomiting, prevention Postoperative nausea and/or vomiting, treatment or rescue therapy Pregnancy-associated nausea and vomiting Radiation therapy-associated nausea and vomiting, rescue therapy |
| Progesterone | Assisted reproductive technology, luteal phase support Estrogen therapy-associated endometrial hyperplasia, prevention Secondary amenorrhea, diagnostic aid Spontaneous preterm birth, prevention Uterine bleeding, abnormal |
| Propofol | General anesthesia Rapid sequence intubation outside the operating room Sedation Status epilepticus, refractory |
| Propranolol | Akathisia, antipsychotic-induced Angina, chronic stable Atrial fibrillation/flutter Essential tremor Hypertension Migraine, prevention Myocardial infarction, early treatment and secondary prevention Performance anxiety disorder Pheochromocytoma Postural orthostatic tachycardia syndrome Supraventricular tachycardia Thyroid storm Thyrotoxicosis Tremor, lithium-induced, moderate to severe Variceal hemorrhage prophylaxis Ventricular arrhythmias |
| Psyllium | Constipation Reduce risk of coronary heart disease Diabetes mellitus, type 2 Irritable bowel syndrome, unspecified |
| Quetiapine | Agitation/Aggression and psychosis associated with dementia, severe or refractory Agitation and/or delirium, ICU Bipolar disorder Delusional infestation Generalized anxiety disorder Major depressive disorder Obsessive-compulsive disorder, treatment-resistant Posttraumatic stress disorder Psychosis in Parkinson disease Schizophrenia |
| Quinapril | Heart failure with reduced ejection fraction Hypertension |
| Quinidine | Atrial fibrillation/flutter, pharmacological conversion Paroxysmal atrial fibrillation/flutter, maintenance of sinus rhythm Malaria, treatment Ventricular arrhythmias |
| Rabeprazole | Aspiration prophylaxis in patients undergoing anesthesia Barrett esophagus Dyspepsia, functional Eosinophilic esophagitis Gastroesophageal reflux disease Hypersecretory conditions Nonsteroidal anti-inflammatory drugs-induced ulcers, primary prevention Peptic ulcer disease, treatment and secondary prevention |
| Ramipril | Acute coronary syndrome Heart failure with reduced ejection fraction Hypertension, chronic Proteinuric chronic kidney disease Reduction in risk of myocardial infarction, stroke, and death from cardiovascular causes |
| Ramipril and hydrochlorothiazide | Hypertension |
| Ranitidine | Duodenal ulcer Gastric ulcer, benign Gastroesophageal reflux disease Heartburn prevention or relief |
| Repaglinide | Diabetes mellitus, type 2, treatment |
| Risedronate | Osteoporosis, fracture risk reduction Paget disease of bone, treatment Prostate cancer, bone loss associated with androgen deprivation therapy |
| Risperidone | Agitation/Aggression associated with psychiatric disorders, substance intoxication, or other organic causes Agitation/Aggression and psychosis associated with dementia, severe or refractory Bipolar disorder Delusional disorder Delusional infestation Huntington disease-associated chorea, moderate to severe Major depressive disorder, treatment resistant Obsessive-compulsive disorder, treatment resistant Schizophrenia Tourette syndrome, management of tics |
| Rituximab including biosimilars | Acute lymphoblastic leukemia, B-cell precursor, CD20-positive Antibody-mediated rejection, treatment Burkitt lymphoma Chronic lymphocytic leukemia Dermatomyositis/Polymyositis, refractory disease Eosinophilic granulomatosis with polyangiitis Graft-versus-host disease, chronic, steroid-refractory Granulomatosis with polyangiitis or microscopic polyangiitis Hodgkin lymphoma, nodular lymphocyte-predominate, advanced IgG4-related disease Immune thrombocytopenia Lupus nephritis, diffuse or focal, resistant Membranous nephropathy, primary Minimal change disease, frequently relapsing disease Mixed cryoglobulinemia syndrome, moderate to severe disease Mucosa-associated lymphoid tissue lymphoma, advanced Multiple sclerosis Myasthenia gravis, refractory or muscle-specific tyrosine kinase antibody-positive Neuromyelitis optica, relapse prevention Non-Hodgkin lymphomas Pemphigus vulgaris or pemphigus foliaceus Posttransplant lymphoproliferative disorder Primary CNS lymphoma Rheumatoid arthritis Thrombotic thrombocytopenic purpura, acquired Waldenstrom macroglobulinemia Warm autoimmune hemolytic anemia |
| Rituximab including biosimilars of rituximab | Antibody-mediated rejection, treatment Burkitt lymphoma Chronic lymphocytic leukemia Dermatomyositis/Polymyositis, refractory disease Graft-versus-host disease, chronic, refractory Granulomatosis with polyangiitis or microscopic polyangiitis Hodgkin lymphoma, nodular lymphocyte-predominate, advanced IgG4-related disease Immune thrombocytopenia Lupus nephritis, refractory Membranous nephropathy, primary Minimal change disease, frequently relapsing disease Mixed cryoglobulinemia syndrome, moderate to severe disease Mucosa-associated lymphoid tissue lymphoma, advanced Multiple sclerosis Myasthenia gravis, refractory or muscle-specific tyrosine kinase antibody-positive Neuromyelitis optica, relapse prevention Non-Hodgkin lymphomas Pemphigus vulgaris or pemphigus foliaceus, moderate to severe Posttransplant lymphoproliferative disorder Primary CNS lymphoma Rheumatoid arthritis Thrombotic thrombocytopenic purpura, acquired Waldenstrom macroglobulinemia Warm autoimmune hemolytic anemia |
| Rivastigmine | Alzheimer disease, mild to moderate Alzheimer disease, severe Dementia with Lewy bodies Parkinson disease dementia, mild to moderate Vascular dementia, comorbid |
| Rizatriptan | Migraine, moderate to severe, acute treatment |
| Rocuronium | Endotracheal intubation or mechanical ventilation during surgery, neuromuscular blockade Mechanically ventilated patients in the ICU, neuromuscular blockade |
| Ropinirole | Parkinson disease Restless legs syndrome |
| Rosuvastatin | Heterozygous familial hypercholesterolemia Homozygous familial hypercholesterolemia Prevention of atherosclerotic cardiovascular disease Transplantation |
| Rupatadine | Allergic rhinitis Chronic spontaneous urticaria |
| Salmeterol | Asthma/Bronchospasm Chronic obstructive pulmonary disease, maintenance Exercise-induced bronchospasm |
| Saxagliptin | Diabetes mellitus, type 2, treatment |
| Scopolamine | Gastrointestinal/genitourinary spasm Malignant bowel obstruction, inoperable Motion sickness, prevention Postoperative nausea and/or vomiting, prevention Sialorrhea Terminal airway secretions |
| Selegiline | Major depressive disorder Parkinson disease, adjunctive therapy Parkinson disease, monotherapy |
| Semaglutide | Diabetes mellitus, type 2, treatment Weight management, chronic |
| Senna | Constipation Constipation |
| Sertraline | Binge eating disorder Body dysmorphic disorder Bulimia nervosa Generalized anxiety disorder Major depressive disorder Obsessive-compulsive disorder Panic disorder Posttraumatic stress disorder Premature ejaculation Premenstrual dysphoric disorder Social anxiety disorder |
| Sildenafil | Erectile dysfunction High-altitude pulmonary edema Pulmonary arterial hypertension Raynaud phenomenon |
| Simethicone | Gas retention |
| Simvastatin | Heterozygous familial hypercholesterolemia Homozygous familial hypercholesterolemia Prevention of atherosclerotic cardiovascular disease Transplantation, post kidney |
| Sitagliptin | Diabetes mellitus, type 2, treatment |
| Sitagliptin and metformin | Diabetes mellitus, type 2, treatment |
| Sodium bicarbonate | Antacid Cardiac arrest, prolonged Cardiac conduction delays due to sodium channel blockade in overdose Hyperkalemia, severe/emergent Metabolic acidosis, acute severe Metabolic acidosis in patients with chronic kidney disease Neutralize lidocaine with epinephrine dental anesthetic Prevention of contrast-induced nephropathy Renal tubular acidosis Urine alkalinization |
| Solifenacin | Overactive bladder |
| Spironolactone | Acne vulgaris, females, moderate to severe Ascites due to cirrhosis Heart failure Hirsutism, females Hormone therapy for transgender females, assigned male at birth Hypertension, chronic Primary aldosteronism Bronchopulmonary dysplasia Edema Hypertension Primary aldosteronism, treatment |
| Sucralfate | Duodenal ulcer Gastroesophageal reflux disease in pregnancy Marginal (anastomotic) ulceration after bariatric surgery Oral ulcers, simple recurrent stomatitis and ulcers associated with Behcet disease Proctitis due to radiation Upper GI toxicity following radiation therapy |
| Sulfasalazine | Ankylosing spondylitis Crohn disease, mild to moderately active Psoriatic arthritis Rheumatoid arthritis Ulcerative colitis Inflammatory bowel disease Juvenile idiopathic arthritis Desensitization regimen |
| Sumatriptan | Cluster headache, acute Cyclic vomiting syndrome, abortive therapy Migraine, moderate to severe, acute treatment |
| Tacrolimus | Atopic dermatitis Oral lichen planus Psoriasis Pyoderma gangrenosum Vitiligo |
| Tadalafil | Benign prostatic hyperplasia Erectile dysfunction High-altitude pulmonary edema Pulmonary arterial hypertension |
| Tamsulosin | Benign prostatic hyperplasia Chronic prostatitis/chronic pelvic pain syndrome in males Lower urinary tract symptoms in males Ureteral stent-related urinary symptoms, treatment Ureteral stone(s) expulsion |
| Telmisartan | Cardiovascular risk reduction Hypertension, chronic |
| Telmisartan and amlodipine | Hypertension |
| Temazepam | Insomnia, sleep onset or sleep maintenance |
| Terazosin | Benign prostatic hyperplasia Hypertension Ureteral calculi expulsion |
| Terbinafine | Onychomycosis Sporotrichosis, lymphocutaneous and cutaneous Tinea infections |
| Terbutaline | Asthma, refractory or severe exacerbation Asthma, intermittent symptom relief Extravasation management, sympathomimetic vasoconstrictors Tocolysis |
| Testosterone | Hormone therapy for transgender males Hypogonadism, male |
| Tetracycline | Acne vulgaris, inflammatory, moderate to severe Cholera, treatment Hidradenitis suppurativa Malaria, treatment, uncomplicated Pityriasis lichenoides chronica Plague Rosacea, moderate to severe or unresponsive to topical therapy Syphilis Tularemia |
| Theophylline | Bradycardia, heart transplantation Dipyridamole- or regadenoson-induced adverse reactions during nuclear cardiac stress testing, reversal Reversible airflow obstruction, acute symptoms Reversible airflow obstruction, chronic conditions |
| Thioridazine | Schizophrenia |
| Ticagrelor | Acute coronary syndrome Coronary artery disease and high risk for ischemic cardiovascular events, primary prevention Minor ischemic stroke or high-risk transient ischemic attack Percutaneous coronary intervention for stable ischemic heart disease |
| Tigecycline | Intra-abdominal infection Pneumonia, community-acquired Skin/skin structure infection, complicated |
| Tiotropium | Asthma, moderate to severe, maintenance Chronic obstructive pulmonary disease, maintenance |
| Tobramycin | Bloodstream infection Cerebrospinal fluid shunt infection Cystic fibrosis, acute pulmonary exacerbation Meningitis, bacterial Peritonitis, treatment Plague, treatment Pneumonia, hospital-acquired or ventilator-associated Sepsis or septic shock, adjunctive empiric gram-negative coverage Urinary tract infection, complicated |
| Tofacitinib | Ankylosing spondylitis COVID-19, hospitalized patients Psoriasis Psoriatic arthritis Rheumatoid arthritis Ulcerative colitis |
| Topiramate | Alcohol use disorder, moderate to severe Binge eating disorder Headache, cluster Headache, short-lasting unilateral neuralgiform attacks Migraine, prevention Seizures Tremor, essential Weight gain, antipsychotic-induced |
| Tramadol | Pain management, moderate to severe Premature ejaculation |
| Trandolapril | Hypertension Post-myocardial infarction heart failure or left ventricular dysfunction Heart failure with reduced ejection fraction |
| Tranexamic acid | Abnormal uterine bleeding, nonacute Dental procedures in patients on oral anticoagulant therapy Hemoptysis, treatment Hereditary angioedema, long-term prophylaxis Hereditary hemorrhagic telangiectasia, epistaxis or other bleeding sites Intracranial hemorrhage associated with thrombolytic treatment Perioperative prevention of blood loss and transfusion Postpartum hemorrhage, prevention Postpartum hemorrhage, treatment Tooth extraction in patients with hemostatic defects Trauma-associated hemorrhage or traumatic brain injury |
| Trazodone | Aggressive or agitated behavior associated with dementia Insomnia, sleep onset and sleep maintenance Major depressive disorder |
| Triamcinolone | Aphthous stomatitis, mild to moderate Atopic dermatitis Contact dermatitis Genital pruritus Psoriasis, plaque Seborrheic dermatitis Stasis dermatitis |
| Triamterene | Edema |
| Trifluoperazine | Schizophrenia |
| Trimebutine | Irritable bowel syndrome Postoperative paralytic ileus |
| Trimethoprim | Acne vulgaris Pneumocystis pneumonia, treatment Urinary tract infection |
| Trimethoprim-sulfamethoxazole | Bite wound infection, prophylaxis or treatment Brucellosis Chronic obstructive pulmonary disease, acute exacerbation Diabetic foot infection, mild Diarrhea, infectious Intra-abdominal infection Intracranial abscess and spinal epidural abscess Mastitis, lactational Melioidosis infection Meningitis, bacterial Nocardiosis Osteomyelitis due to methicillin-resistant S. aureus Plague Prostatitis Prosthetic joint infection Q fever, acute symptomatic Septic arthritis due to methicillin-resistant S. aureus Sexually transmitted infections Skin and soft tissue infection Spontaneous bacterial peritonitis, prophylaxis Surgical prophylaxis Urinary tract infection |
| Ubrogepant | Migraine, moderate to severe, acute treatment |
| Ulipristal | Emergency contraception |
| Umeclidinium | Chronic obstructive pulmonary disease, maintenance |
| Umeclidinium and vilanterol | Chronic obstructive pulmonary disease, maintenance |
| Urea | Hyperkeratotic conditions |
| Valacyclovir | Bell palsy, new onset Cytomegalovirus, prevention in allogeneic hematopoietic cell transplant recipients Herpes simplex virus, meningitis Herpes simplex virus, mucocutaneous infection Herpes simplex virus, prevention in immunocompromised patients Herpes zoster, treatment Herpes zoster ophthalmicus Varicella, uncomplicated, treatment Varicella zoster virus, acute retinal necrosis Varicella zoster virus, prevention in immunocompromised patients |
| Valproate | Bipolar disorder Focal onset seizures and generalized onset seizures Migraine, intractable and status migrainosus Migraine, prevention Status epilepticus |
| Valsartan | Acute coronary syndromes Heart failure with reduced ejection fraction Hypertension, chronic Proteinuric chronic kidney disease |
| Valsartan and amlodipine | Hypertension |
| Vancomycin | Bloodstream infection Cerebrospinal fluid shunt infection Cystic fibrosis, acute pulmonary exacerbation, moderate to severe Diabetic foot infection, moderate to severe Endocarditis, treatment Endophthalmitis, treatment Intra-abdominal infection, health care-associated Intracranial abscess or spinal epidural abscess Meningitis, bacterial Osteomyelitis Peritonitis, treatment Pneumonia, as a component of empiric therapy or pathogen-specific therapy for methicillin-resistant S. aureus Prosthetic joint infection Sepsis/septic shock Septic arthritis, without prosthetic material Skin and soft tissue infection Surgical prophylaxis Surgical site infection Toxic shock syndrome, staphylococcal |
| Vardenafil | Erectile dysfunction Pulmonary arterial hypertension Raynaud phenomenon |
| Varenicline | Smoking cessation |
| Venlafaxine | Generalized anxiety disorder Major depressive disorder Migraine, prevention Narcolepsy with cataplexy Neuropathic pain associated with diabetes mellitus Obsessive-compulsive disorder Panic disorder Posttraumatic stress disorder Premenstrual dysphoric disorder Social anxiety disorder Vasomotor symptoms associated with menopause |
| Vitamin A | Vitamin A deficiency, treatment Vitamin A deficiency, prophylaxis in patients at high risk for deficiency Xerophthalmia, treatment |
| Vortioxetine | Major depressive disorder |
| Warfarin | Anticoagulation |
| Zafirlukast | Asthma, maintenance therapy Chronic urticaria |
| Zoledronic acid | Bone metastases from solid tumors Breast cancer, bone loss associated with aromatase inhibitor therapy in postmenopausal patients Breast cancer, early stage, adjuvant therapy in postmenopausal patients Hypercalcemia of malignancy Multiple myeloma Prostate cancer, bone loss associated with androgen deprivation therapy Osteoporosis, fracture risk reduction Paget disease |
| Zolmitriptan | Cluster headache, treatment Menstrual migraine, prophylaxis Migraine, moderate to severe, acute treatment |
| Zopiclone | Insomnia, sleep onset or sleep maintenance |
| Zuclopenthixol | Agitation/Aggression associated with schizophrenia or psychotic episodes Schizophrenia |
Content on this page has not been checked for accuracy. The author's credentials have not been confirmed. Always use multiple peer-reviewed scholarly sources and good clinical judgement in your decision making.
The Compendium platform was created by David Kwinter, MD, CCFP(EM).