| Drug | Usual dose | Renal dosing |
| Amoxicillin | 500-1000 mg PO TID |
EGFR >30: no change EGFR 10-30: 250-500 mg PO q12h EGFR <10: 250-500 mg PO q12-24h HD: 250-500 mg po q12-24h PD: 250-500 mg po q12h |
| Amoxicillin/Clavulanate |
500/125 mg PO q8h OR 875/125 mg PO q12h |
Same as amoxicillin |
|
Cephalexin (Keflex) |
250-500 mg PO QID |
EGFR >30: no change EGFR 15-30: 250-500 mg PO q8-12h EGFR <15: 250-500 mg PO q12-24h |
|
Ceftriaxone (Rocephin) |
1-2 g IV q24h |
EGFR >15: no change EGFR <15: no change |
|
Cefuroxime (Ceftin) |
500 mg PO q12h |
EGFR >30: no change EGFR 10-30: 250 mg PO q12h EGFR <10: 250 mg PO q24h |
| Ciprofloxacin | 500-750 mg PO q12h |
EGFR >50: no change EGFR 30-50: 250-500 mg PO q12h EGFR <30: 500 mg PO q24h Dialysis: 250-500 mg PO q24h |
|
Nitrofurantoin (Macrobid) |
100 mg PO q12h |
EGFR >45: no change EGFR 30-45: no change, may use with caution for short courses |
|
Trimethaprim-sulfamethoxazole (Bactrim, Septra, Sulfatrim) |
160/800 (DS) mg PO q12h |
EGFR >30: no change EGFR 15-30: take 1 DS dose PO once then 1 SS dose PO q12h EGFR <15: take 1 SS dose PO once then 1 SS dose PO q24h |
