Etiology
Transient bacteremia following an injury that seeds a patient's valve(s)
Abnormal valves predispose to endocarditis because turbulent flow denudes the endocardium, inviting bacterial colonization
Infection of native heart valves is most commonly caused by Streptococcus viridans
Sx
Progressive fatigue
Chronic waxing and waning low-grade fever
Tx
Empiric broad-spectrum antibacterial coverage upon admission
e.g. Vancomycin + Gentamicin
Obtain cultures and sensitivities
S. viridans highly susceptible to penicillin is best treated with IV penicillin G or IV ceftriaxone
Do not use an oral antibiotic to treat endocarditis