Treats
     Nausea/vomiting (see n/v tx)
     Diabetic gastroparesis
Dosing
     10 mg PO/IM q8h PRN
     10 mg IV over 1-2 min q8h PRN
Mechanism of action
     Most doses
          Blocks dopamine receptors
          Increases lower esophageal sphincter tone
          Enhances upper GI tract response to ACh causing enhanced motility and accelerated gastric emptying without stimulating gastric, biliary or pancreatic secretions
     At higher doses
          Blocks serotonin receptors in CTZ of the CNS

     

     

Content on this page has not been checked for accuracy. The author's credentials have not been confirmed. Always use multiple peer-reviewed scholarly sources and good clinical judgement in your decision making.

The Compendium platform was created by David Kwinter, MD, CCFP(EM).

Dr. Kwinter is a Cayman Family Doctor. He runs a Family Medicine Clinic at Cayman Medical in George Town, Grand Cayman, Cayman Islands.