Loop diuretic. Inhibits Na-K-2Cl symporter in the thick ascending limb of the loop of Henle.
Indications
     Third line for tx HTN
     Most appropriate for the treatment of HTN that is complicated by
          Reduced GFR (<30-40mL) OR
          Volume overload syndromes (CHF or nephrotic syndrome)
A/E
     Loops lose calcium
     Severe hypokalemia
     Electrolyte imbalances
     Ototoxicity
Note
     Can lower BP, but less effective in long term than Thiazides
     Furosemide has a shorter duration of action than thiazides (less than 6 hours)
     Torsemide is longer active (>12 hours)
Treats
     Left ventricular failure

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The Compendium platform was created by David Kwinter, MD, CCFP(EM).

Dr. Kwinter is a Cayman Family Doctor. He runs a Family Medicine Clinic at Cayman Medical in George Town, Grand Cayman, Cayman Islands.